OS-01 (O-304 / ATX-304) 100mg (30 Capsules) For Sale | Pan-AMPK Activator

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They call it “exercise in a capsule.” That’s not hype — it’s a description of what OS-01 (O-304) actually does at the cellular level. As the world’s first orally available pan-AMPK activator that works by suppressing AMPK dephosphorylation rather than depleting cellular ATP, it activates the same energy-sensing enzyme that exercise triggers — without the energy deficit that conventional AMPK activators like metformin require to do it. For researchers studying senescence, mitochondrial function, metabolic signaling, and cellular aging, that distinction makes OS-01 one of the most unique and sought-after tool compounds available today.

OS-01 (O-304) for sale here — 100mg per capsule, 30 capsules per bottle, ≥99% purity, COA included, research grade, ships globally.

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What Is OS-01 (O-304 / ATX-304)?

OS-01 — also known as O-304, ATX-304, and synonymously listed as OWL833 — is a synthetic small-molecule compound belonging to the benzamide class. Its molecular formula is C16H11Cl2N3O2S, molar mass 380.25 g/mol (CAS: 1261289-04-6, PubChem: 50923806). It was developed as a first-in-class pan-AMPK activator by Amplifier Therapeutics (a Cambrian Bio pipeline company) and is currently in clinical development for obesity and cardiometabolic disease.

What makes OS-01 (O-304) genuinely different from every other AMPK activator in the research toolkit is how it activates AMPK. Metformin — the most widely used AMPK activator in metabolic research — works by inhibiting mitochondrial Complex I, which reduces ATP production and raises the AMP/ATP ratio, which then indirectly activates AMPK. That indirect mechanism means you can’t cleanly isolate AMPK signaling without also confounding your data with cellular energy depletion.

OS-01 bypasses that problem entirely. It stabilizes the phosphorylated form of AMPK (p-T172) by suppressing the dephosphorylation of pAMPK — keeping AMPK in its active state even in the presence of high ATP levels. No energy depletion required. No AMP/ATP ratio manipulation. Direct, clean AMPK activation that lets you study the pathway itself — not the side effects of starving cells into activating it. That’s the mechanistic advantage that has made O-304 a go-to compound for labs studying AMPK biology, energy homeostasis, mitochondrial biogenesis, senescence, and aging.

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What AMPK Does And Why Researchers Care So Much

AMPK (5′-AMP-activated protein kinase) is the master energy sensor of the cell. When cellular energy drops, AMPK activates — switching the cell from energy-consuming anabolic processes to energy-generating catabolic ones. It triggers mitochondrial biogenesis, promotes autophagy, enhances fatty acid oxidation, improves glucose uptake, suppresses gluconeogenesis, and modulates cellular senescence pathways. It’s the molecular switch that connects exercise, caloric restriction, and cellular stress to longevity-associated biological changes.

Every major research direction in metabolic health, aging biology, and cardiometabolic disease runs through AMPK at some point. That’s why a clean, direct, orally bioavailable pan-AMPK activator that works without energy depletion is such a powerful research asset — and why labs studying everything from diabetes to senescence to liver disease to kidney aging to cardiovascular protection are ordering OS-01 (O-304).

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How OS-01 Differs From Other AMPK Activators

The peripherally restricted action of OS-01 (ATX-304) is another key research advantage — it keeps its effects outside the central nervous system, reducing confounding variables in studies focused on peripheral metabolic and mitochondrial signaling.

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Uses of OS-01 (O-304)

Metabolic Signaling and Glucose Homeostasis The core application. OS-01 (O-304) activates AMPK across all subunit combinations, promoting GLUT4-mediated glucose uptake in muscle cells, suppressing hepatic gluconeogenesis, and improving insulin sensitivity markers in experimental models — all through a mechanistically clean pathway that doesn’t require energetic stress to trigger the signal.

Mitochondrial Function and Biogenesis Because AMPK is a master regulator of mitochondrial health, O-304 is widely used in mitochondrial research. It promotes PGC-1α and TFAM expression — key drivers of mitochondrial biogenesis — enhances oxidative phosphorylation, and acts as a mild mitochondrial uncoupler that increases basal oxygen consumption in cell models. Researchers studying mitochondrial aging, dysfunction, and recovery find it particularly useful.

Cellular Senescence Research OS-01 (O-304) modulates transcriptional responses associated with cellular senescence — including markers like P16INK4A and γH2AX — through AMPK-driven autophagy and mitochondrial quality control. Labs studying the biology of cellular aging, stress-adaptive mechanisms, and tissue maintenance are among the most active buyers of this compound globally.

Liver Disease Models (MASLD/NAFLD) A 2025 study in JCI Insight confirmed ATX-304 reduces body fat mass, lowers blood cholesterol, and mitigates liver steatosis and fibrosis development in progressive fatty liver disease mouse models — positioning it as a valuable tool compound for hepatology research.

Kidney Aging and Protection Research published in Frontiers in Pharmacology showed O-304 protects against cellular senescence and age-related fibrosis in kidney tissue by promoting energy metabolism and autophagy — making it relevant for renal aging and nephroprotection research protocols.

Cardiovascular and Vascular Research O-304 improves microvascular perfusion through nitric oxide signaling and promotes VEGF-related angiogenesis in skeletal muscle — both AMPK-mediated effects relevant to cardiovascular, peripheral artery disease, and exercise physiology research models.

Obesity and GLP-1 Combination Research Amplifier Therapeutics presented preclinical data at ENDO 2025 showing ATX-304 in combination with semaglutide — studying body weight, food intake, and body composition including after semaglutide withdrawal. This is an emerging research direction with significant clinical relevance.

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Product Specifications

Important naming note: Some product stock may carry the OS-01 label. This product is not affiliated with, endorsed by, or associated with OneSkin’s registered OS-01® trademark. The compound is O-304 / ATX-304 — a distinct research-grade AMPK activator.

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How to Use OS-01 (O-304) — Storage and Handling Guide

Storage

OS-01 (O-304) capsules are convenient to store — no cold chain required for the capsule form. Keep at room temperature in the original packaging, away from direct light and moisture. For long-term storage of any extracted powder, use −20°C in amber containers sealed tightly after each use. Shelf life is 36 months under correct storage conditions.

Handling in Research Protocols

OS-01 (O-304) is a small-molecule compound in capsule form — not a peptide, not a lyophilized powder requiring reconstitution. Standard small-molecule laboratory handling applies. Wear nitrile gloves when handling the compound. Work in a clean, low-humidity environment. For cell-based assays requiring the active compound in solution, dissolve in DMSO for stock preparation, then dilute to working concentration in your assay buffer. Verify solubility at your target concentration before use in cell culture.

Common Research Applications by Format

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Why Buy the 30-Capsule Kit?

Serious OS-01 (O-304) research runs on consistent supply. Whether you’re running dose-response experiments, comparative AMPK activator studies, longitudinal senescence protocols, or combination studies with GLP-1 compounds — a 30-capsule bottle at 100mg per capsule gives you 3,000mg of verified, batch-documented active compound. Enough to complete multi-arm designs without switching batches mid-protocol and introducing lot-to-lot variables into your data. One verified bottle. One COA. One reliable dataset foundation.

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FAQs About OS-01 (O-304 / ATX-304)

1. What is OS-01 (O-304 / ATX-304) and what does it do?

OS-01 (O-304) is a synthetic small-molecule pan-AMPK activator — the first of its class that stabilizes active phosphorylated AMPK without depleting cellular ATP. It activates AMPK across all subunit combinations, promoting mitochondrial biogenesis, glucose uptake, fatty acid oxidation, autophagy, and cellular senescence modulation. It’s currently in clinical development for obesity and cardiometabolic disease by Amplifier Therapeutics.

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2. What is the difference between OS-01 and OneSkin’s OS-01?

Completely different products. OneSkin’s OS-01® is a registered trademark skin care peptide compound for topical cosmetic use. The research compound sold here is O-304 (ATX-304) — a small-molecule pan-AMPK activator with an entirely different chemical structure, mechanism, and application. Some older product labeling may show “OS-01” for this compound — that labeling is not affiliated with or endorsed by OneSkin Technologies in any way.

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3. Is O-304 the same as metformin?

No — and the mechanistic difference matters enormously for research. Metformin activates AMPK indirectly by inhibiting mitochondrial Complex I, reducing ATP, and raising the AMP/ATP ratio. O-304 (OS-01) activates AMPK directly by suppressing pAMPK dephosphorylation — keeping AMPK active without energy depletion. This means you can study AMPK signaling cleanly without the confounding effects of cellular energy stress that metformin introduces.

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4. Is OS-01 (ATX-304) FDA approved?

No. ATX-304 (O-304) is currently in clinical development by Amplifier Therapeutics (a Cambrian Bio company) for obesity and cardiometabolic disease. It is not yet FDA-approved for any therapeutic use. It is available strictly for qualified laboratory research use only — not for human consumption.

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5. What makes OS-01 (O-304) an “exercise mimetic”?

AMPK is the same energy-sensing enzyme that exercise activates in muscle and liver cells. Because O-304 directly activates AMPK — including promoting mitochondrial biogenesis, improving microvascular perfusion, enhancing fatty acid oxidation, and boosting glucose uptake — it mimics many of the downstream cellular signals that exercise triggers. This is why it’s commonly described as an exercise mimetic in research contexts, particularly for studying populations or models where exercise is limited.

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6. What research areas use OS-01 (O-304 / ATX-304)?

Active research applications include: metabolic syndrome and type 2 diabetes models, MASLD/NAFLD liver disease research, cellular senescence and aging biology, mitochondrial function and biogenesis, kidney protection from age-related fibrosis, cardiovascular and microvascular perfusion studies, obesity models (including GLP-1 combination protocols), and pain pathway research via AMPK-mediated analgesia models.

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7. How should OS-01 (O-304) capsules be stored?

Capsules store at room temperature in their original packaging, away from direct light and moisture — shelf life is 36 months under these conditions. For extracted powder used in solution-based assays, store at −20°C in amber, sealed containers. Avoid repeated freeze-thaw cycles of any reconstituted solution. No cold chain or refrigeration is required for capsule storage under normal laboratory conditions.

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8. Can OS-01 (O-304) be combined with other research compounds?

Yes — and combination research is an active direction. ATX-304 + semaglutide is currently being studied in preclinical obesity models by Amplifier Therapeutics, with data presented at ENDO 2025. In research protocol design, O-304 is also commonly studied alongside 5-Amino-1MQ (NNMT inhibitor) for complementary NAD+/AMPK coverage, and alongside mitochondrial-targeted compounds like SS-31 (Elamipretide) or MOTS-c for multi-pathway metabolic and aging research.

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9. Is OS-01 (ATX-304) a peptide?

No. Despite sometimes being grouped with peptide-based research compounds, OS-01 (O-304 / ATX-304) is a synthetic small molecule — a benzamide derivative. It is not a peptide, does not have an amino acid chain, and does not require peptide-specific handling, reconstitution, or storage protocols. Its oral bioavailability and small-molecule structure make it distinct from peptide-based metabolic research tools.

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10. What is the shelf life of OS-01 (O-304) capsules?

36 months from manufacture date under correct storage conditions — room temperature, original packaging, away from light and moisture. This extended shelf life makes the 30-capsule bottle a practical long-term lab investment for ongoing research programs without supply continuity concerns.

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11. How does OS-01 relate to cellular senescence research?

AMPK activation by O-304 promotes autophagy — the cellular cleanup process that removes damaged organelles and misfolded proteins that accumulate with aging and drive the senescent cell phenotype. It also reduces markers of cellular senescence including P16INK4A and γH2AX in experimental models, and modulates β-catenin signaling linked to senescence-associated fibrosis. This multi-pathway influence on senescence biology makes it a compelling tool compound for labs studying cellular aging, tissue maintenance, and stress-adaptive mechanisms.

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12. Can OS-01 (O-304) be stacked with GLP-1 research compounds?

Yes — and there’s growing preclinical evidence supporting this combination. Because ATX-304 preserves muscle mass and promotes fat oxidation through AMPK-driven mitochondrial biogenesis, while GLP-1 agonists primarily reduce caloric intake and delay gastric emptying — the two mechanisms are genuinely complementary for body composition research. Amplifier Therapeutics presented data at ENDO 2025 on exactly this combination design using ATX-304 + semaglutide in diet-induced obesity models.

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⚠️ Research Use Only: OS-01 (O-304 / ATX-304) is intended strictly for in vitro laboratory research. Buyers confirm compliance with all applicable local regulations. Not affiliated with OneSkin Technologies or their registered OS-01® trademark.